Line-scanning reflectance confocal microscopy of human skin: Comparison of full-pupil and divided-pupil configurations

Line-scanning, with pupil engineering and the use of linear array detectors, may enable simple, small, and

low-cost confocal microscopes for clinical imaging of human epithelial tissues. However, a fundamental understanding

of line-scanning performance within the highly scattering and aberrating conditions of human

tissue is necessary, to translate from benchtop instrumentation to clinical implementation. The results of a

preliminary investigation for reflectance imaging in skin are reported.