Quote of the evening from the 3 y/o: “I can’t talk cause I’m busy rocking out”
07 July 2012
In vivo volumetric imaging of microcirculation within human skin under psoriatic conditions using optical microangiography
Qin J., Jiang J., An L., Gareau D. Wank R.K.
Background and Objective: There is a growing body of evidence suggesting that vascular abnormalities may play crucial role in several dermatologic diseases, such as psoriasis, port wine stain, and skin cancer. To improve our understanding of vascular involvement in these skin conditions, there is a need for a non-invasive imaging modality capable of assessing 3D microcirculations within skin tissue beds in vivo. This study aims to demonstrate whether ultra-high sensitive optical microangiography (UHS-OMAG)is feasible to visualize skin microcirculations
in 3D and to quantify microvascular vessel density under
normal and psoriatic conditions in vivo.
Study Design/Material and Methods: An UHS-OMAG
system operating at 1,310nm wavelength was used for in
vivo imaging of microcirculation in human skin. The
system has a spatial resolution of 10 mm20 mm (axial lateral), running at 280 fps to acquire3Dimaging dataset to
represent morphology and capillary level microvascular
blood perfusion within the scanned skin tissue volume. The
sensitivity of the system to the blood flow is as low as4 mm/
second. With this system, we performed the imaging
experiments on the skin of a volunteer with stable plaquetype
psoriasis. The microcirculation and structural information
of normal and diseased skins were compared both
qualitatively and quantitatively.
Results: The UHS-OMAG is capable of differentiating the
microcirculation within the normal skins from that in the
psoriatic skins. The 3D optical images show that the blood
vessel elongation and the dense network in the psoriatic
lesion skin, the appearance of which is not observed within
the normal skin. Based on the results obtained from one
subject, the statistical analyses show that higher blood
vessel density presented within the psoriasis lesion skin
than that of the normal skin.
Conclusions: UHS-OMAG can be a valuable tool for
imaging skin microcirculations non-invasively with highspeed
and high-sensitivity, and therefore may have a
useful role in future clinical diagnosis and treatment
of dermatologic diseases such as psoriasis in human
subjects. Lasers Surg. Med. 43:122–129, 2011.
2011 Wiley-Liss, Inc.